1. J.J. Kang, A. Ohoka, and C.A. Sarkar. "Designing multivalent and multispecific biologics." Annual Review of Chemical and Biomolecular Engineering, in press (2024). Link
     
  2. H. Venkatachalapathy, Z. Yang, S.M. Azarin, C.A. Sarkar†, and E. Batchelor†. "Pulsed stimuli entrain p53 to synchronize single cells and modulate cell-fate determination." bioRxiv, 2023.10.24.563786 (2023). †Co-corresponding authors. Link
     
  3. H. Venkatachalapathy, C. Brzakala, E. Batchelor, S.M. Azarin†, and C.A. Sarkar†. "Inertial effect of cell state velocity on the quiescence-proliferation fate decision in breast cancer." bioRxiv, 2023.05.22.541793 (2023). †Co-corresponding authors. Link
     
  4. A. Ohoka and C.A. Sarkar. "Facile display of homomultivalent proteins for in vitro selections." ACS Synthetic Biology, 12:634-638 (2023). Link
     
  5. J.C. Stark†, M.A. Gray†, S. Wisnovsky, I. Ibarlucea-Benitez, N.M. Riley, M.K. Ribi, M. Lustig, W.J. Errington, B. Bruncsics, C.A. Sarkar, T. Valerius, J.V. Ravetch, and C.R. Bertozzi. "Antibody-lectin chimeras for glyco-immune checkpoint blockade." bioRxiv, 2022.10.26.513931 (2022). †Contributed equally. Link
     
  6. B. Bruncsics†, W.J. Errington†, and C.A. Sarkar. "MVsim is a toolset for quantifying and designing multivalent interactions." Nature Communications, 13:5029 (2022). †Contributed equally. Link | MVsim
     
  7. Q. Zhang, S.M. Azarin, and C.A. Sarkar. "Model-guided engineering of DNA sequences with predictable site-specific recombination rates." Nature Communications, 13:4152 (2022). Link
     
  8. G.C. Markou and C.A. Sarkar. "A cell-free approach to identify binding hotspots in plant immune receptors." Scientific Reports, 12:501 (2022). Link
     
  9. G.C. Markou, A. Ohoka, and C.A. Sarkar. "Engineering a minimal leucine-rich repeat IgG-binding module." Applied Biochemistry and Biotechnology, 194:1636-1644 (2022). Link
     
  10. H. Venkatachalapathy, S.M. Azarin, and C.A. Sarkar. "Trajectory-based energy landscapes of gene regulatory networks." Biophysical Journal, 120:687-698 (2021). Link
     
  11. W.J. Errington†, B. Bruncsics†, and C.A. Sarkar. "Mechanisms of non-canonical binding dynamics in multivalent protein-protein interactions." Proceedings of the National Academy of Sciences USA, 116:25659-25667 (2019). †Contributed equally. Link
     
  12. N.A. Shah and C.A. Sarkar. "Variable cellular decision-making behavior in a constant synthetic network topology." BMC Bioinformatics, 20:237 (2019). Link
     
  13. Z. Ye and C.A. Sarkar. "Towards a quantitative understanding of cell identity." Trends in Cell Biology, 28:1030-1048 (2018). Link
     
  14. F.W. Sadler, I. Dodevski, and C.A. Sarkar. "RNA thermometers for the PURExpress system." ACS Synthetic Biology, 7:292-296 (2018). Link
     
  15. A.L. Kane, B. Al-Shayeb, P.V. Holec, S. Rajan, N.E. Le Mieux, S.C. Heinsch, S. Psarska, K.G. Aukema, C.A. Sarkar, E.A. Nater and J.A. Gralnick. "Toward bioremediation of methylmercury using silica encapsulated Escherichia coli harboring the mer operon." PLOS ONE, 11:e0147036 (2016). Link
     
  16. N.A. Shah, M. Levesque, A. Raj, and C.A. Sarkar. "Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue." Journal of Cell Science, 128:3009-3017 (2015). Link
     
  17. I. Dodevski†, G.C. Markou†, and C.A. Sarkar. "Conceptual and methodological advances in cell-free directed evolution." Current Opinion in Structural Biology, 33:1-7 (2015). †Contributed equally. Link
     
  18. N.A. Shah and C.A. Sarkar. "Computationally guided design of robust gene circuits." Methods in Molecular Biology, 1244:167-178 (2015). Link
     
  19. D.T.W. Ng and C.A. Sarkar. "NP-Sticky: a web server for optimizing DNA ligation with non-palindromic sticky ends." Journal of Molecular Biology, 426:1861-1869 (2014). Link | NP-Sticky
     
  20. M.S. Magaraci†, A. Veerakumar†, P. Qiao, A. Amurthur, J.Y. Lee, J.S. Miller‡, M. Goulian, and C.A. Sarkar‡. "Engineering Escherichia coli for light-activated cytolysis of mammalian cells." ACS Synthetic Biology, 3:944-948 (2014). †Contributed equally; ‡co-corresponding authors. Link
     
  21. H.M. Mehta, M. Futami, T. Glaubach, Q. Yang, D.W. Lee, J.R. Andolina, Z. Whichard, M. Quinn, H. Lu, W.-M. Kao, B. Przychodzen, C.A. Sarkar, A. Minella, J.P. Maciejewski, and S.J. Corey. "Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition." Leukemia, 28:1041-1051 (2014). Link
     
  22. C.A. Sarkar. "Concentrating (on) native proteins to control cell fate." Science, 341:1349-1351 (2013). Link
     
  23. P.A. Barendt, N.A. Shah, G.A. Barendt, P.A. Kothari, and C.A. Sarkar. "Evidence for context-dependent complementarity of non-Shine-Dalgarno ribosome binding sites to Escherichia coli rRNA." ACS Chemical Biology, 8:958-966 (2013). Link
     
  24. P.A. Barendt†, D.T.W. Ng†, C.N. McQuade, and C.A. Sarkar. "Streamlined protocol for mRNA display." ACS Combinatorial Science, 15:77-81 (2013). †Contributed equally. Link | Cover
     
  25. D.T.W. Ng and C.A. Sarkar. "Engineering signal peptides for enhanced protein secretion from Lactococcus lactis." Applied and Environmental Microbiology, 79:347-356 (2013). Link
     
  26. S.T. Jung, W. Kelton, T.H. Kang, D.T.W. Ng, J.T. Andersen, I. Sandlie, C.A. Sarkar, and G. Georgiou. "Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity." ACS Chemical Biology, 8:368-375 (2013). Link
     
  27. D.T.W. Ng and C.A. Sarkar. "Model-guided ligation strategy for optimal assembly of DNA libraries." Protein Engineering, Design, and Selection, 25:669-678 (2012). Link
     
  28. P.A. Barendt, N.A. Shah, G.A. Barendt, and C.A. Sarkar. "Broad-specificity mRNA-rRNA complementarity in efficient protein translation." PLOS Genetics, 8:e1002598 (2012). Link
     
  29. S. Palani and C.A. Sarkar. "Transient noise amplification and gene expression synchronization in a bistable mammalian cell-fate switch." Cell Reports, 1:215-224 (2012). Link
     
  30. E.C. O'Shaughnessy and C.A. Sarkar. "Analyzing and engineering cell signaling modules with synthetic biology." Current Opinion in Biotechnology, 23:785-790 (2012). Link
     
  31. N.A. Shah and C.A. Sarkar. "Robust network topologies for generating switch-like cellular responses." PLOS Computational Biology, 7:e1002085 (2011). Link
     
  32. S. Palani and C.A. Sarkar. "Synthetic conversion of a graded receptor signal into a tunable, reversible switch." Molecular Systems Biology, 7:480 (2011). Link
     
  33. D.T.W. Ng and C.A. Sarkar. "Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000." Biotechnology and Bioengineering, 108:1987-1996 (2011). Link
     
  34. E.C. O'Shaughnessy, S. Palani, J.J. Collins†, and C.A. Sarkar†. "Tunable signal processing in synthetic MAP kinase cascades." Cell, 144:119-131 (2011). †Co-corresponding authors. Link
     
  35. C. Zahnd, C.A. Sarkar†, and A. Plückthun†. "Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution." Protein Engineering, Design, and Selection, 23:175-184 (2010). †Co-corresponding authors. Link
     
  36. Z.L. Whichard, C.A. Sarkar, M. Kimmel, and S.J. Corey. "Hematopoiesis and its disorders: a systems biology approach." Blood, 115:2339-2347 (2010). Link
     
  37. S. Palani and C.A. Sarkar. "Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors." PLOS Computational Biology, 5:e1000518 (2009). Link
     
  38. P.A. Barendt and C.A. Sarkar. "Cell-Free Display Systems for Protein Engineering" in Protein Engineering and Design, Jennifer Cochran and Sheldon Park, eds., Taylor and Francis Group, Boca Raton, FL (2009). Link
     
  39. C.A. Sarkar. "Principles of Computational Cell Biology – From Protein Complexes to Cellular Networks." The Quarterly Review of Biology, 84:303-303 (2009). Link
     
  40. P. Milovnik, D. Ferrari, C.A. Sarkar, and A. Plückthun. "Selection and characterization of DARPins specific for the neurotensin receptor 1." Protein Engineering, Design, and Selection, 22:357-366 (2009). Link
     
  41. C.A. Sarkar†, I. Dodevski†, M. Kenig, S. Dudli, A. Mohr, E. Hermans, and A. Plückthun. "Directed evolution of a G-protein coupled receptor for expression, stability, and binding selectivity." Proceedings of the National Academy of Sciences USA, 105:14808-14813 (2008). †Contributed equally. Link
     
  42. S. Palani and C.A. Sarkar. "Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch." Biophysical Journal, 95:1575-1589 (2008). Link
     
  43. S. Kubetzko†, C.A. Sarkar†, and A. Plückthun. "Protein PEGylation decreases observed target association rates via a dual blocking mechanism." Molecular Pharmacology, 68:1439-1454 (2005). †Contributed equally. Link
     
  44. C.A. Sarkar, K. Lowenhaupt, P.J. Wang, T. Horan, and D.A. Lauffenburger. "Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues." Biotechnology Progress, 19:955-964 (2003). Link
     
  45. M.S. Ricci, C.A. Sarkar, E.M. Fallon, D.A. Lauffenburger, and D.N Brems. "pH dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor." Protein Science, 12:1030-1038 (2003). Link
     
  46. C.A. Sarkar and D.A. Lauffenburger. "Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo." Molecular Pharmacology, 63:147-158 (2003). Link
     
  47. C.A. Sarkar, K. Lowenhaupt, T. Horan, T.C. Boone, B. Tidor, and D.A. Lauffenburger. "Rational cytokine design for increased lifetime and enhanced potency using pH-activated 'histidine switching.'" Nature Biotechnology, 20:908-913 (2002). Link