1. H. Venkatachalapathy, Z. Yang, S.M. Azarin, C.A. Sarkar, and E. Batchelor. "Pulsed stimuli entrain p53 to synchronize single cells and modulate cell-fate determination." bioRxiv, 2023.10.24.563786 (2023). Co-corresponding authorsLink
  2. H. Venkatachalapathy, C. Brzakala, E. Batchelor, S.M. Azarin, and C.A. Sarkar. "Inertial effect of cell state velocity on the quiescence-proliferation fate decision in breast cancer." bioRxiv, 2023.05.22.541793 (2023). Co-corresponding authorsLink
  3. A. Ohoka and C.A. Sarkar. "Facile display of homomultivalent proteins for in vitro selections." ACS Synthetic Biology, 12:634-638 (2023). Link
  4. J.C. Stark, M.A. Gray, S. Wisnovsky, I. Ibarlucea-Benitez, N.M. Riley, M.K. Ribi, M. Lustig, W.J. Errington, B. Bruncsics, C.A. Sarkar, T. Valerius, J.V. Ravetch, and C.R. Bertozzi. "Antibody-lectin chimeras for glyco-immune checkpoint blockade." bioRxiv, 2022.10.26.513931 (2022). Contributed equally. Link
  5. B. Bruncsics, W.J. Errington, and C.A. Sarkar. "MVsim is a toolset for quantifying and designing multivalent interactions." Nature Communications, 13:5029 (2022). Contributed equally. Link | MVsim
  6. Q. Zhang, S.M. Azarin, and C.A. Sarkar. "Model-guided engineering of DNA sequences with predictable site-specific recombination rates." Nature Communications, 13:4152 (2022). Link
  7. G.C. Markou and C.A. Sarkar. "A cell-free approach to identify binding hotspots in plant immune receptors." Scientific Reports, 12:501 (2022). Link
  8. G.C. Markou, A. Ohoka, and C.A. Sarkar. "Engineering a minimal leucine-rich repeat IgG-binding module." Applied Biochemistry and Biotechnology, 194:1636-1644 (2022). Link
  9. H. Venkatachalapathy, S.M. Azarin, and C.A. Sarkar. "Trajectory-based energy landscapes of gene regulatory networks." Biophysical Journal, 120:687-698 (2021). Link
  10. W.J. Errington, B. Bruncsics, and C.A. Sarkar. "Mechanisms of non-canonical binding dynamics in multivalent protein-protein interactions." Proceedings of the National Academy of Sciences USA, 116:25659-25667 (2019). Contributed equally. Link
  11. N.A. Shah and C.A. Sarkar. "Variable cellular decision-making behavior in a constant synthetic network topology." BMC Bioinformatics, 20:237 (2019). Link
  12. Z. Ye and C.A. Sarkar. "Towards a quantitative understanding of cell identity." Trends in Cell Biology, 28:1030-1048 (2018). Link
  13. F.W. Sadler, I. Dodevski, and C.A. Sarkar. "RNA thermometers for the PURExpress system." ACS Synthetic Biology, 7:292-296 (2018). Link
  14. A.L. Kane, B. Al-Shayeb, P.V. Holec, S. Rajan, N.E. Le Mieux, S.C. Heinsch, S. Psarska, K.G. Aukema, C.A. Sarkar, E.A. Nater and J.A. Gralnick. "Toward bioremediation of methylmercury using silica encapsulated Escherichia coli harboring the mer operon." PLOS ONE, 11:e0147036 (2016). Link
  15. N.A. Shah, M. Levesque, A. Raj, and C.A. Sarkar. "Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue." Journal of Cell Science, 128:3009-3017 (2015). Link
  16. I. Dodevski, G.C. Markou, and C.A. Sarkar. "Conceptual and methodological advances in cell-free directed evolution." Current Opinion in Structural Biology, 33:1-7 (2015). Contributed equally. Link
  17. N.A. Shah and C.A. Sarkar. "Computationally guided design of robust gene circuits." Methods in Molecular Biology, 1244:167-178 (2015). Link
  18. D.T.W. Ng and C.A. Sarkar. "NP-Sticky: a web server for optimizing DNA ligation with non-palindromic sticky ends." Journal of Molecular Biology, 426:1861-1869 (2014). Link | NP-Sticky
  19. M.S. Magaraci, A. Veerakumar, P. Qiao, A. Amurthur, J.Y. Lee, J.S. Miller, M. Goulian, and C.A. Sarkar. "Engineering Escherichia coli for light-activated cytolysis of mammalian cells." ACS Synthetic Biology, 3:944-948 (2014). Contributed equallyco-corresponding authors. Link
  20. H.M. Mehta, M. Futami, T. Glaubach, Q. Yang, D.W. Lee, J.R. Andolina, Z. Whichard, M. Quinn, H. Lu, W.-M. Kao, B. Przychodzen, C.A. Sarkar, A. Minella, J.P. Maciejewski, and S.J. Corey. "Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition." Leukemia, 28:1041-1051 (2014). Link
  21. C.A. Sarkar. "Concentrating (on) native proteins to control cell fate." Science, 341:1349-1351 (2013). Link
  22. P.A. Barendt, N.A. Shah, G.A. Barendt, P.A. Kothari, and C.A. Sarkar. "Evidence for context-dependent complementarity of non-Shine-Dalgarno ribosome binding sites to Escherichia coli rRNA." ACS Chemical Biology, 8:958-966 (2013). Link
  23. P.A. Barendt, D.T.W. Ng, C.N. McQuade, and C.A. Sarkar. "Streamlined protocol for mRNA display." ACS Combinatorial Science, 15:77-81 (2013). Contributed equallyLink | Cover
  24. D.T.W. Ng and C.A. Sarkar. "Engineering signal peptides for enhanced protein secretion from Lactococcus lactis." Applied and Environmental Microbiology, 79:347-356 (2013). Link
  25. S.T. Jung, W. Kelton, T.H. Kang, D.T.W. Ng, J.T. Andersen, I. Sandlie, C.A. Sarkar, and G. Georgiou. "Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity." ACS Chemical Biology, 8:368-375 (2013). Link
  26. D.T.W. Ng and C.A. Sarkar. "Model-guided ligation strategy for optimal assembly of DNA libraries." Protein Engineering, Design, and Selection, 25:669-678 (2012). Link
  27. P.A. Barendt, N.A. Shah, G.A. Barendt, and C.A. Sarkar. "Broad-specificity mRNA-rRNA complementarity in efficient protein translation." PLOS Genetics, 8:e1002598 (2012). Link
  28. S. Palani and C.A. Sarkar. "Transient noise amplification and gene expression synchronization in a bistable mammalian cell-fate switch." Cell Reports, 1:215-224 (2012). Link
  29. E.C. O'Shaughnessy and C.A. Sarkar. "Analyzing and engineering cell signaling modules with synthetic biology." Current Opinion in Biotechnology, 23:785-790 (2012). Link
  30. N.A. Shah and C.A. Sarkar. "Robust network topologies for generating switch-like cellular responses." PLOS Computational Biology, 7:e1002085 (2011). Link
  31. S. Palani and C.A. Sarkar. "Synthetic conversion of a graded receptor signal into a tunable, reversible switch." Molecular Systems Biology, 7:480 (2011). Link
  32. D.T.W. Ng and C.A. Sarkar. "Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000." Biotechnology and Bioengineering, 108:1987-1996 (2011). Link
  33. E.C. O'Shaughnessy, S. Palani, J.J. Collins, and C.A. Sarkar. "Tunable signal processing in synthetic MAP kinase cascades." Cell, 144:119-131 (2011). Co-corresponding authorsLink
  34. C. Zahnd, C.A. Sarkar, and A. Plückthun. "Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution." Protein Engineering, Design, and Selection, 23:175-184 (2010). Co-corresponding authorsLink
  35. Z.L. Whichard, C.A. Sarkar, M. Kimmel, and S.J. Corey. "Hematopoiesis and its disorders: a systems biology approach." Blood, 115:2339-2347 (2010). Link
  36. S. Palani and C.A. Sarkar. "Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors." PLOS Computational Biology, 5:e1000518 (2009). Link
  37. P.A. Barendt and C.A. Sarkar. "Cell-Free Display Systems for Protein Engineering" in Protein Engineering and Design, Jennifer Cochran and Sheldon Park, eds., Taylor and Francis Group, Boca Raton, FL (2009). Link
  38. C.A. Sarkar. "Principles of Computational Cell Biology – From Protein Complexes to Cellular Networks." The Quarterly Review of Biology, 84:303-303 (2009). Link
  39. P. Milovnik, D. Ferrari, C.A. Sarkar, and A. Plückthun. "Selection and characterization of DARPins specific for the neurotensin receptor 1." Protein Engineering, Design, and Selection, 22:357-366 (2009). Link
  40. C.A. Sarkar, I. Dodevski, M. Kenig, S. Dudli, A. Mohr, E. Hermans, and A. Plückthun. "Directed evolution of a G-protein coupled receptor for expression, stability, and binding selectivity." Proceedings of the National Academy of Sciences USA, 105:14808-14813 (2008). Contributed equallyLink
  41. S. Palani and C.A. Sarkar. "Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch." Biophysical Journal, 95:1575-1589 (2008). Link
  42. S. Kubetzko, C.A. Sarkar, and A. Plückthun. "Protein PEGylation decreases observed target association rates via a dual blocking mechanism." Molecular Pharmacology, 68:1439-1454 (2005). Contributed equally. Link
  43. C.A. Sarkar, K. Lowenhaupt, P.J. Wang, T. Horan, and D.A. Lauffenburger. "Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues." Biotechnology Progress, 19:955-964 (2003). Link
  44. M.S. Ricci, C.A. Sarkar, E.M. Fallon, D.A. Lauffenburger, and D.N Brems. "pH dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor." Protein Science, 12:1030-1038 (2003). Link
  45. C.A. Sarkar and D.A. Lauffenburger. "Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo." Molecular Pharmacology, 63:147-158 (2003). Link
  46. C.A. Sarkar, K. Lowenhaupt, T. Horan, T.C. Boone, B. Tidor, and D.A. Lauffenburger. "Rational cytokine design for increased lifetime and enhanced potency using pH-activated 'histidine switching.'" Nature Biotechnology, 20:908-913 (2002). Link