Note: Check Dr. Sarkar's PubMed repository for free access to articles behind paywalls.

 

  1. J.C. Stark†, M.A. Gray†, S. Wisnovsky, I. Ibarlucea-Benitez, N.M. Riley, M.K. Ribi, M. Lustig, W.J. Errington, B. Bruncsics, C.A. Sarkar, T. Valerius, J.V. Ravetch, and C.R. Bertozzi. "Antibody-lectin chimeras for glyco-immune checkpoint blockade." Nature Biotechnology, accepted (2025). †Contributed equally.
     
  2. V.A. Garcia, P.M. Eberts, B.M. Ogle, and C.A. Sarkar. "Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination." Drug Delivery, 32 (2025).
     
  3. H. Venkatachalapathy, S. Dallon, Z. Yang, S.M. Azarin, C.A. Sarkar†, and E. Batchelor†. "Pulsed stimuli enable p53 phase resetting to synchronize single cells and modulate cell fate." Molecular Systems Biology, 21:390-412 (2025). †Co-corresponding authors. 
     
  4. V.A. Garcia, C.A. Sarkar, and B.M. Ogle. "Syncytial therapeutics: receptor-specific and direct-to-cytosol biologic drug delivery mediated by measles fusion complex." Journal of Controlled Release, 380:967-975 (2025).
     
  5. H. Venkatachalapathy, C. Brzakala, E. Batchelor, S.M. Azarin†, and C.A. Sarkar†. "Inertial effect of cell state velocity on the quiescence-proliferation fate decision." npj Systems Biology and Applications, 10:111 (2024). †Co-corresponding authors.
     
  6. K.A. Lemke, C.A. Sarkar, and S.M. Azarin. "Rapid retinoic acid-induced trophoblast cell model from human induced pluripotent stem cells." Scientific Reports, 14:18204 (2024).
     
  7. J.J. Kang, A. Ohoka, and C.A. Sarkar. "Designing multivalent and multispecific biologics." Annual Review of Chemical and Biomolecular Engineering, 15:293-314 (2024). 
     
  8. A. Ohoka and C.A. Sarkar. "Facile display of homomultivalent proteins for in vitro selections." ACS Synthetic Biology, 12:634-638 (2023).
     
  9. B. Bruncsics†, W.J. Errington†, and C.A. Sarkar. "MVsim is a toolset for quantifying and designing multivalent interactions." Nature Communications, 13:5029 (2022). †Contributed equally. | Link to MVsim
     
  10. Q. Zhang, S.M. Azarin, and C.A. Sarkar. "Model-guided engineering of DNA sequences with predictable site-specific recombination rates." Nature Communications, 13:4152 (2022).
     
  11. G.C. Markou and C.A. Sarkar. "A cell-free approach to identify binding hotspots in plant immune receptors." Scientific Reports, 12:501 (2022).
     
  12. G.C. Markou, A. Ohoka, and C.A. Sarkar. "Engineering a minimal leucine-rich repeat IgG-binding module." Applied Biochemistry and Biotechnology, 194:1636-1644 (2022).
     
  13. H. Venkatachalapathy, S.M. Azarin, and C.A. Sarkar. "Trajectory-based energy landscapes of gene regulatory networks." Biophysical Journal, 120:687-698 (2021).
     
  14. W.J. Errington†, B. Bruncsics†, and C.A. Sarkar. "Mechanisms of non-canonical binding dynamics in multivalent protein-protein interactions." Proceedings of the National Academy of Sciences USA, 116:25659-25667 (2019). †Contributed equally.
     
  15. N.A. Shah and C.A. Sarkar. "Variable cellular decision-making behavior in a constant synthetic network topology." BMC Bioinformatics, 20:237 (2019).
     
  16. Z. Ye and C.A. Sarkar. "Towards a quantitative understanding of cell identity." Trends in Cell Biology, 28:1030-1048 (2018).
     
  17. F.W. Sadler, I. Dodevski, and C.A. Sarkar. "RNA thermometers for the PURExpress system." ACS Synthetic Biology, 7:292-296 (2018).
     
  18. A.L. Kane, B. Al-Shayeb, P.V. Holec, S. Rajan, N.E. Le Mieux, S.C. Heinsch, S. Psarska, K.G. Aukema, C.A. Sarkar, E.A. Nater and J.A. Gralnick. "Toward bioremediation of methylmercury using silica encapsulated Escherichia coli harboring the mer operon." PLOS ONE, 11:e0147036 (2016).
     
  19. N.A. Shah, M. Levesque, A. Raj, and C.A. Sarkar. "Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue." Journal of Cell Science, 128:3009-3017 (2015).
     
  20. I. Dodevski†, G.C. Markou†, and C.A. Sarkar. "Conceptual and methodological advances in cell-free directed evolution." Current Opinion in Structural Biology, 33:1-7 (2015). †Contributed equally.
     
  21. N.A. Shah and C.A. Sarkar. "Computationally guided design of robust gene circuits." Methods in Molecular Biology, 1244:167-178 (2015).
     
  22. D.T.W. Ng and C.A. Sarkar. "NP-Sticky: a web server for optimizing DNA ligation with non-palindromic sticky ends." Journal of Molecular Biology, 426:1861-1869 (2014). | Link to NP-Sticky
     
  23. M.S. Magaraci†, A. Veerakumar†, P. Qiao, A. Amurthur, J.Y. Lee, J.S. Miller‡, M. Goulian, and C.A. Sarkar‡. "Engineering Escherichia coli for light-activated cytolysis of mammalian cells." ACS Synthetic Biology, 3:944-948 (2014). †Contributed equally; ‡co-corresponding authors.
     
  24. H.M. Mehta, M. Futami, T. Glaubach, Q. Yang, D.W. Lee, J.R. Andolina, Z. Whichard, M. Quinn, H. Lu, W.-M. Kao, B. Przychodzen, C.A. Sarkar, A. Minella, J.P. Maciejewski, and S.J. Corey. "Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition." Leukemia, 28:1041-1051 (2014).
     
  25. C.A. Sarkar. "Concentrating (on) native proteins to control cell fate." Science, 341:1349-1351 (2013).
     
  26. P.A. Barendt, N.A. Shah, G.A. Barendt, P.A. Kothari, and C.A. Sarkar. "Evidence for context-dependent complementarity of non-Shine-Dalgarno ribosome binding sites to Escherichia coli rRNA." ACS Chemical Biology, 8:958-966 (2013).
     
  27. P.A. Barendt†, D.T.W. Ng†, C.N. McQuade, and C.A. Sarkar. "Streamlined protocol for mRNA display." ACS Combinatorial Science, 15:77-81 (2013). †Contributed equally.  | Featured on journal cover
     
  28. D.T.W. Ng and C.A. Sarkar. "Engineering signal peptides for enhanced protein secretion from Lactococcus lactis." Applied and Environmental Microbiology, 79:347-356 (2013).
     
  29. S.T. Jung, W. Kelton, T.H. Kang, D.T.W. Ng, J.T. Andersen, I. Sandlie, C.A. Sarkar, and G. Georgiou. "Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity." ACS Chemical Biology, 8:368-375 (2013).
     
  30. D.T.W. Ng and C.A. Sarkar. "Model-guided ligation strategy for optimal assembly of DNA libraries." Protein Engineering, Design, and Selection, 25:669-678 (2012).
     
  31. P.A. Barendt, N.A. Shah, G.A. Barendt, and C.A. Sarkar. "Broad-specificity mRNA-rRNA complementarity in efficient protein translation." PLOS Genetics, 8:e1002598 (2012).
     
  32. S. Palani and C.A. Sarkar. "Transient noise amplification and gene expression synchronization in a bistable mammalian cell-fate switch." Cell Reports, 1:215-224 (2012).
     
  33. E.C. O'Shaughnessy and C.A. Sarkar. "Analyzing and engineering cell signaling modules with synthetic biology." Current Opinion in Biotechnology, 23:785-790 (2012).
     
  34. N.A. Shah and C.A. Sarkar. "Robust network topologies for generating switch-like cellular responses." PLOS Computational Biology, 7:e1002085 (2011).
     
  35. S. Palani and C.A. Sarkar. "Synthetic conversion of a graded receptor signal into a tunable, reversible switch." Molecular Systems Biology, 7:480 (2011).
     
  36. D.T.W. Ng and C.A. Sarkar. "Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000." Biotechnology and Bioengineering, 108:1987-1996 (2011).
     
  37. E.C. O'Shaughnessy, S. Palani, J.J. Collins†, and C.A. Sarkar†. "Tunable signal processing in synthetic MAP kinase cascades." Cell, 144:119-131 (2011). †Co-corresponding authors.
     
  38. C. Zahnd, C.A. Sarkar†, and A. Plückthun†. "Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution." Protein Engineering, Design, and Selection, 23:175-184 (2010). †Co-corresponding authors.
     
  39. Z.L. Whichard, C.A. Sarkar, M. Kimmel, and S.J. Corey. "Hematopoiesis and its disorders: a systems biology approach." Blood, 115:2339-2347 (2010).
     
  40. S. Palani and C.A. Sarkar. "Integrating extrinsic and intrinsic cues into a minimal model of lineage commitment for hematopoietic progenitors." PLOS Computational Biology, 5:e1000518 (2009).
     
  41. P.A. Barendt and C.A. Sarkar. "Cell-Free Display Systems for Protein Engineering" in Protein Engineering and Design, Jennifer Cochran and Sheldon Park, eds., Taylor and Francis Group, Boca Raton, FL (2009).
     
  42. C.A. Sarkar. "Principles of Computational Cell Biology – From Protein Complexes to Cellular Networks." The Quarterly Review of Biology, 84:303-303 (2009).
     
  43. P. Milovnik, D. Ferrari, C.A. Sarkar, and A. Plückthun. "Selection and characterization of DARPins specific for the neurotensin receptor 1." Protein Engineering, Design, and Selection, 22:357-366 (2009).
     
  44. C.A. Sarkar†, I. Dodevski†, M. Kenig, S. Dudli, A. Mohr, E. Hermans, and A. Plückthun. "Directed evolution of a G-protein coupled receptor for expression, stability, and binding selectivity." Proceedings of the National Academy of Sciences USA, 105:14808-14813 (2008). †Contributed equally.
     
  45. S. Palani and C.A. Sarkar. "Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch." Biophysical Journal, 95:1575-1589 (2008).
     
  46. S. Kubetzko†, C.A. Sarkar†, and A. Plückthun. "Protein PEGylation decreases observed target association rates via a dual blocking mechanism." Molecular Pharmacology, 68:1439-1454 (2005). †Contributed equally.
     
  47. C.A. Sarkar, K. Lowenhaupt, P.J. Wang, T. Horan, and D.A. Lauffenburger. "Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues." Biotechnology Progress, 19:955-964 (2003).
     
  48. M.S. Ricci, C.A. Sarkar, E.M. Fallon, D.A. Lauffenburger, and D.N Brems. "pH dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor." Protein Science, 12:1030-1038 (2003).
     
  49. C.A. Sarkar and D.A. Lauffenburger. "Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo." Molecular Pharmacology, 63:147-158 (2003).
     
  50. C.A. Sarkar, K. Lowenhaupt, T. Horan, T.C. Boone, B. Tidor, and D.A. Lauffenburger. "Rational cytokine design for increased lifetime and enhanced potency using pH-activated 'histidine switching.'" Nature Biotechnology, 20:908-913 (2002).